Pyrimidine, 4-chloro-5-fluoro-2-methyl-

Pyrimidine, 4-chloro-5-fluoro-2-methyl- - Names and Identifiers

Name	4-Chloro-5-fluoro-2-methylpyrimidine
Synonyms	4-Chloro-5-fluoro-2-methylpyrimidine 5-Fluoro-4-chloro-2-methylpyrimidine 4-CHLORO-5-FLUORO-2-METHYL-PYRIMIDINE Pyrimidine, 4-chloro-5-fluoro-2-methyl- pyrimidine, 4-chloro-5-fluoro-2-methyl-
CAS	898044-50-3
InChI	InChI=1/C5H4ClFN2/c1-3-8-2-4(7)5(6)9-3/h2H,1H3

Pyrimidine, 4-chloro-5-fluoro-2-methyl- - Physico-chemical Properties

Molecular Formula	C5H4ClFN2
Molar Mass	146.55
Density	1.352±0.06 g/cm3(Predicted)
Boling Point	176.9±20.0 °C(Predicted)
Flash Point	60.8°C
Vapor Presure	1.44mmHg at 25°C
pKa	-0.65±0.29(Predicted)
Storage Condition	Inert atmosphere,Store in freezer, under -20°C
Refractive Index	1.505

Pyrimidine, 4-chloro-5-fluoro-2-methyl- - Introduction

It is an organic compound with the formula C5H4ClFN2 and a structure containing a 4-chloro group, a 5-fluoro group and a 2-methyl group.

The properties of this compound include:
-Appearance: Colorless or light yellow crystal
-Melting point: 43-44°C
-Boiling point: 240°C
-density: 1.38 g/cm ^ 3
-Solubility: Slightly soluble in water, soluble in organic solvents such as chloroform, ethanol, acetone, etc.

It is mainly used as an intermediate in organic synthesis. It can be used to synthesize biologically active compounds, such as drugs, pesticides and dyes. For example, it can be used in the synthesis of anticancer drugs, fungicides and other active ingredients in the field of medicine.

There are many ways to prepare the compound, mainly through the chemical modification of pyrimidine. Common preparation methods include:
-first chlorinated pyrimidine to obtain 4-chloro pyrimidine;
-Then 4-chloropyrimidine reacts with fluorine gas under alkaline conditions to obtain 4-chloro-5-fluoropyrimidine;
-Finally, the 2-methyl group is introduced through a methylation reaction.

When using the calcium, it is necessary to pay attention to safety and follow the general laboratory procedures. This compound is irritating and may cause irritation to the eyes, skin and respiratory tract. Therefore, appropriate protective equipment such as safety glasses, gloves and respiratory protection must be worn during operation, and the experiment must be carried out under well-ventilated conditions. Avoid inhalation, ingestion or contact with skin. If contact occurs, rinse immediately with plenty of water and seek medical help.

Last Update：2024-04-09 20:48:19